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  • Life IVF Center
  • Before You Start
  • Assisted Reproductive
  • IVF Lab
  • Procedure Room
  • Recovery Room
  • Medication Tech
  • Hotel Information
  • Air Port Information
  • FAQ
Life IVF Center
 

Life IVF Center is a unique fertility center in Southern California. We specialize in Natural Cycle IVF (NC-IVF) and Minimal Stimulation IVF (MS-IVF). In our center, we will not exclude you for IVF treatment because of your age, number of follicles, FSH or AMH level or financial status. For patients with advanced maternal age, we will try our best to give you a chance to conceive with your own egg.

We understand that conventional IVF treatment is very expensive and stressful. Our goal is to provide a gentle, safe, successful and affordable IVF option to all patients who need assisted reproductive technologies (ART).

Because each patient is different, our treatment protocol for each patient is different. Based on medical conditions and fertility treatment goals, we will design a specific and individualized protocol for each patient.

We believe that natural conception is the best way to have a healthy baby. We will assist patients to achieve pregnancy through a natural method if possible. When a patient needs IVF, we offer a Natural Cycle IVF (NC-IVF) as the first option if she meets the indication. In NC-IVF, patient will complete an IVF treatment without any fertility medication. It is a very safe and cost effective option for many patients.

We also specialize in Minimal Stimulation IVF (MS-IVF), which primarily uses an oral medication with only few injections. Patients will have minimal fertility medication exposure, but achieve comparable IVF outcome as conventional IVF. For some patients, especially with decreased ovarian reserve, it has much better results. It reduces the side effects of medication and significantly decreases the cost of fertility treatment. In our center, we also promote single embryo transfer, which will reduce the multiple gestation. As a state-of-the-art fertility center, we offer full range of fertility services including pre-implantation genetic diagnosis (PGD) and 24 Chromosome PGS, oocyte vitrification, and donor egg and surrogacy program.

We invite you to experience our NC-IVF and MS-IVF. We strive to deliver the most compassionate and personalized care!

     
Before You Start
 

All patients are required to do pre-IVF testing and counseling done before starting the IVF process. This will allow the Doctor and staff members at Life IVF Center to better assess the patient’s overall health condition. After the patient is established we will better be able to provide any necessary prescriptions relating to the patient’s treatment plan, complete the appropriate informed consent documents, review and clarify the patient’s financial obligations. 

 

Initial Consultation
Patients are required to have a pre-IVF consultation with the Doctor. Patients can download the History and Physical forms to fill out.  The nurses will input the information into the EMR system and then the Doctor will review your medical history and any past IVF records. If you have any past medical records to share, please bring them with you and give them to our front desk. You can ask questions and discuss with the Doctor during your consult on what options you have and how to improve your chances of becoming pregnant. For out of state patients, we also offer an initial phone consultation.

Financial consultation
- Our financial advisors will meet with patients in person or on the phone to explain our different treatment packages and prices. They will review the fees involved, and discuss the various options for you.
- They will also help you to verify if you have any insurance coverage.
- At the end, patients need to sign a financial agreement and financial obligation prior to starting the treatment.

Consent forms
It is very important for patients and patients’ partners to read through the consent forms, initial and sign as needed. If patients don't understand an item, please feel free to ask the doctor. If patients have not signed the any consent before the appointment, we will need to reschedule the appointment. If the consent forms are still not signed on the procedure day, the procedure may be cancelled.

Infectious Disease Panel (ID panel)

In order to be compliant with the regulations of the state law, we are required to obtain the infectious disease testing for both of you and your partner prior to every IVF treatment. You will need to do a blood test for HIV/AIDS and Hepatitis B&C. HIV/AIDs and Hepatitis B&C are blood borne infectious diseases, they can be passed through the placenta and cause long-term unhealth consequences for both of the mother and the child. HTLV I&II are human RNA retrovirus, can cause a serious sexually transmitted disease related to leukemia, myelopathy and Syphilis (RPR). Additionally, the blood test still helps us to check for Rubella (German measles) and varicella (Chicken pox) because these two diseases can cause a serious birth defect. The Infectious Disease Testing is a necessary preparation before any IVF treatment started and could help you to have a healthy baby.
If you have already done the above pre-IVF testing within one year and have the results, you may forward all of your papers to our LIC hormone Lab. Please E-mail everything to: LICHormoneLab@gmail.com or Fax everything to 949 988 1136. Attn: LIC Hormone Lab.

Ovarian Reserve Testing
This test must be done on cycle Day2 or cycle Day3 of your menstrual cycle to evaluate ovarian function. To determine your ovarian reserve, there are several tests are available. It is very important to know your ovarian reserve prior to the beginning of your fertility treatment because it will help us to design the optimal protocol for you.
The tests we are currently using in our office: (1). Cycle Day2 or cycle Day3 FSH level (normal range: 5-10mIU/ml), (2). Baseline antral follicle counts (AFC) (normal range: 5-10 each ovary), (3). AMH (anti-Müllerian hormone )level (normal range: above 2.0ng /ml)

Genetic Testing
The following genetic carrier testing is recommended by American Society for Reproductive Medicine.
1. Cystic fibrosis testing
2. Fragile X testing
Some other genetic testing may be recommended by our doctor after the initial consultation, such as Karyotype and Y chromosome micro-deletion.

Pelvic ultrasound, SIS (Sonohysterogram) testing
All patients need a pelvic ultrasound and SIS test to evaluate the status of the ovaries, tubes, and uterus. The ultrasound can help us evaluate the ovarian, and see the uterine size when any abnormality existed. It can also identify if any fluid accumulated in the tubes.
SIS will help to evaluate the uterine cavity and to determine the tubal patency; therefore, it is very important to finish the SIS test before the embryo transfer. HSG and Hysteroscopy are the alternative SIS tests.

Assisted Reproductive Technology
 

 IVF is a method of assisted reproductive technology by combing female’s egg and the male’s sperm and fertilized outside the body. In
the process, one or more eggs are removed from the ovaries with a very thin needle aspirated through the vaginal wall under the ultrasound guidance. Every patient has their own

Treatment plan.

    After reviewing the blood test results, Dr. Yelian will determine medications that will be used in your specific cycle.
Our center specializes in natural cycle IVF and minimal stimulation IVF. Our philosophy is to use less medication to produce the best quality embryo.
The medications may be used: Necon(OCP), Alesse(OCP), Estrace, Progesterone, Femara, Clomid, Tamoxifen, Gonal-F, Follistim, Menopur, Lupron, Ibuprofen, etc.

Starting Your Cycle
When all of the pre-cycle consultations and testings are completed, you are ready to start the IVF cycles. Please call LIC on the first full flow period day (referred to as cycle Day 1) to schedule a monitoring appointment. The phone number you need to call is '949-788-1133.

During Your Cycle

  • Monitoring Follicular Development

    During the natural cycle (NC) or minimal stimulation cycle (MS), the follicle(s) development is monitored through a combination of blood tests and ultrasounds. The blood tests include Estrodiol (E2), FSH, LH and progesterone (P4). It is important that the tests are done on a specific day, and the patients have to follow the treatment plan under the nurses’ instructions. FOR PATIENTS WHO MONITORED OUTSIDE OF OUR OFFICE, IT IS THE PATIENTS’ RESPONSIBILITIES TO BRING THE RESULTS INTO OUR OFFICE BEFORE 3 PM ON THE SAME DAY. Transvaginal ultrasound will be performed by a LIC ultrasound technician. Prior to the ultrasound exam, please empty your bladder. The SIS exam will be done by Dr. Yelian. It is typically performed from the patient’s menstrual cycle day 6 to 12.

  • Lupron / HCG Trigger

    According to the monitoring results, Dr. Yelian will be able to diagnose that if the eggs are enough matured or the eggs are ready to be retrieved. The patients will get Lupron injection which helps the egg to reach the final maturation process. The Lupron injection will be given in the late evening, and it’s approximately taking from 34 to 36 hours until the egg retrieval procedure. The nurses will instruct the patients about how to do the Lupron injections. A certain date and a certain time will be given by the nurses for Lupron injections, and the patients are responsible to carry out the process by themselves and give injections on time since it will affect the outcomes of egg retrieval. If the patients miss the injection time, please inject the Lupron as soon as you can, and call our office in the next morning to notify the nurses. We may be able to reschedule your egg retrieval day.
Please stop all oral medications (Clomid, Femara) or injections (Bravella, Follistim, Gonal-F, Menopur) on the day of the Lupron injection. The normal dose of Lupron injection is 0.15 ml or 0.2 ml; for some patients we may use HCG to instead, or use both HCG and Lupron as a double trigger. The HCG normal dose is usually 5000 IU or 10,000 IU.

 

On The Day of Egg Retrieval Day
DO NOT WEAR ANY PERFUME, LOTION OR DEODORANT ON THE DAY OF EGG RETRIEVAL PROCEDURE. Perfume, lotion and deodorant are toxic to the eggs. Please eat a light breakfast 2 hours before the procedure (This only applies for patients who are not using IV sedation.)
The Egg Retrieval procedure is performed transvaginally or transabdominally. The staffs who are attending the Egg Retrieval procedure will be: doctor(s), nurse(s), medical assistant(s), and embryologist(s).  An ultrasound will be used to visualize the location of the follicles. A very thin medical needle will pass through the vaginal wall into the ovary. Most of the patients are not being sedated because the whole Egg Retrival procedure is very brief (only a few minutes). It is common to experience mild pain or menstrual–like cramping during the procedure. After the fluid is aspirated into the test tube, the Embryologists will take the aspirated fluid into the embryology lab to evaluate the viable eggs under a microscope.
If the patients are very sensitive to pain, the patients may request a local anesthesia or IV sedation.

  • IV sedation

    FOR IV SEDATION PATIENTS, DO NOT EAT or DRINK AFTER MIDNIGHT OR AT LEASET EIGHT (8) HOURS PERIOR TO YOUR EGG RETRIEVAL PROCEDURE.  
All patients should arrive to LIC 30 minutes earlier than the procedure time. The nurse will ask the patient to change into a procedure gown, and place covers on patient’s head and feet. Patients need to empty bladders before entering the procedure room.
The anesthesiologist will meet with you before the procedure. Please be aware there is an additional fee for the local anesthesia and IV sedation. 

  • Sperm Collection

    During the procedure, the partner will be required to wait in the waiting room. He will be placed into the semen collection room to do a fresh semen specimen collection if egg retrieval is successful.
Optionally male patients can collect semen sample at home, and then drop it off. It has to be on same day. For more information, please ask the receptionist about sperm collection instructions and specimen container prior to the ER appointment. The specimen has to be received within 1 hour after the time of production. DO NOT EXPOSE SPECIMEN TO EXTREME HOT OR COLD TEMPERTURE. Maintaining the specimen at body temperature, and there is no requirement for any sexual abstinence day(s) prior to semen collection. For patient’s safety, we require the male partner to sign consent if he is not be able to  drop off the semen specimen; he must give the permission for his partner to drop off the specimen.
If the patient is planning to use frozen or donor sperm instead of a fresh specimen, please inform the nurses on the day of Lupron shots.

After Egg Retrieval
After 20 to 30 minutes rest, a nurse will check patient’s blood pressure; and have the patient to go to the restroom to remove gauzes. Please place the gauze on the stand inside of the restroom. As well, please inform the nurse immediately if there is any excessive bleeding after removing gauzes.
Patients may experience slight soreness in the next a few days. After the procedure, we recommend the patient to take Tylenol 500mg for 1 to 2 tablets every 4 hours to release pain. DO NOT EXCEED 8 TABLETS IN A 24 HOURS PERIOD.
Patients may experience a scant of spotting from the vagina, but patients should not experience any heavy bleeding. Please report it to the nurse if the bleeding is worse than spotting, or if patients have fever over than 100.4°F.
After the first few days of the procedure, please only take showers; avoid taking baths or hot tubs. We recommend patients to abstain from intercourse or use tampons for 5 to 7 days after the procedure.
For IV sedation patients, the sedative medications used during Egg Retrieval procedure will stay in the body system for up to 24 hours. Therefore, patients need a friend or a family member to drive; and a 24 hours recovery. Please ask the nurse a break letter for 24 hours.

IVF Lab


The sperms, eggs and embryos are handled in the ART lab. All eggs are identified, isolated and evaluated under a sterile environment. After Egg Retrieval, the egg will be identified. And then, it will be placed into an incubator for 4 hours before the insemination or ICSI. On the egg retrieval day, embryologists will talk to you about the number of retrieved eggs. The embryologists also will discuss the embryo culture plan with you.

ICSI (Intra-Cytoplasmic Sperm Injection)

ICSI is one of the most significant advances in ART history in the last 20 years. Only mature eggs can be inseminated. Insemination, whether it is natural or Intra Cytoplasmic Sperm Injection (ICSI), occurs in the afternoon of the retrieval day (Day 0).
During the ICSI procedure, an egg is stabilized under the microscope with a special micro-holding pipette; and a single sperm is picked up by a small needle and injected directly into the egg. Fertilization will be evaluated after18 to 22 hours. ICSI is recommended for male patients who had prior failure in fertilization experiences or significant anti-sperm bodies.
ICSI has a significantly higher fertilization rate; we recommend most of the patients doing ICSI. If patients do not accept ICSI, please notify the embryologists on the same day of Egg Retrieval.
A fertilization check will be done by the embryologists in the next day (Day1). Patients will be notified by a phone call or a text message regarding the fertilization status in the afternoon. PLEASE DO NOT CALL UNLESS PATIENTS HAVE NOT RECEIVED ANY INFORMATION BY 5PM. IF DAY1 IS SUNDAY, PATIENTS WILL BE NOTIFIED ON THE NEXT MONDAY.

Blastocyst culture
Our center policy is once patients have had a failed frozen Day 2 embryo transfer before or a fresh Day 2 embryo transfer, we strongly suggest to culture all embryos to blastocyst; and then transfer. If the embryos become blastocysts during Day5 to Day7, we will freeze the embryos for your next cycle for a frozen embryo transfer (FET).
Sometimes, embryos fail to grow to blastocysts; the implantation rate is still double more than a blastocyst transfer or than a 4-cell stage embryo transfer.

Preimplantation genetic testing
Pre-implantation genetic diagnosis (PGD) is the screening of individual embryos for genetic disorders or gender determination during the IVF process. It is the practice of removing a cell from the developing 8 cells or blastocysts stage embryos to evaluate the cell’s genetic composition and determine which embryos will be the optimal for embryo transfer.
Our lab offers PGS (Preimplantation genetic screening) 5 chromosomes (13, 18, 21, X, Y), PGS 24 (all chromosomes) service and PGD (Pre-implantation diagnosis). It is an optional service and the doctor will discuss with patients whether it will be beneficial IVF cycles.
On Day 3 or Day 5 embryo development, the embryologist will carefully remove a single cell from the 8 cells stage embryo or a 2-3 cells blastocyst stage embryo. Only embryos that contained 6, more cells on Day 3 or a good quality blastocyst on Day 5 will be tested.

The chance of the embryos being damaged during the biopsy procedure is low (about 1%). However, it has not been determined if some undetected damage may result in an increased risk of obstetric complications, fetal abnormalities, or may decreased the chance of achieving pregnancy. Also, the diagnosis may be made on an embryo that is incorrect. Some embryos may contain cells that are genetically normal and, within the same embryo,  other cells which are abnormal. This is called mosaicism. It may result in the transfer of an embryo carrying an abnormal chromosome or genetic abnormality or the failure to transfer a normal embryo.

  Assisted Hatching

 When the embryo develops to the point that it is ready to implant in the endometrium of the uterus, it must hatch out of the egg shell (zona pellucida). If the zona is abnormally thickened or it is a frozen-thawed embryo, it may make it more difficult for the embryo hatch out and implant in the uterus. Assisted hatching is performed in the IVF lab using micromanipulation instruments. Our embryologist will make a hole on the zona before the embryo transfer. There is some evidence that embryos that have undergone zona manipulation for assisted hatching tend to implant one day earlier than unhatched embryos.

Embryo Cryopreservation- Vitrification

LIC uses the most advanced method of cryopreservation. This will allow embryos to be utilized at a later date. Most recent studies have shown that the frozen embryo transfer has higher pregnancy rate than a fresh embryo transfer. LIC offers both egg and embryo vitrification program. The vitrification process has a higher survival rate compared to the old method of “slow freezing”. After Egg Retrieval, patiens will have an opportunity to meet with embryologists to discuss the embryo culture plan, the stage  of embryos, cryopreserved.
                                                                    

embryos, and stages for embryo biopsy and so on.

     After eggs are fertilized, the embryos can be frozen at different stages. At LIC, we frequently freeze at the 4 cells stage (D2) or blastocyst stage (D5).
The blastocyst transfer has a higher pregnancy rate than a Day 2 or Day 3 embryo transfer. Not all embryos can grow into blastocysts. Based on the patient’s specific circumstance, the embryologist will discuss a particular plan for each individual patient. Please respect and follow the embryologist’s recommendations because of their many years of working experiences, and all the decisions are made in your best interest.

Procedure Room
 
 

he embryo transfer is essentially a painless procedure and only takes a few minutes.  DO NOT WEAR ANY PERFUME, LOTION OR DEODORANT ON THE DAY OF EMBRYO TRANSFER. Patients do not need anesthesia for the procedure. Embryologists will explain to patients about the embryo status before the transfer. Please empty your bladder after you change into the procedure clothes in the recovery room. Once the patient’s identity has been verified by an embryologist and a nurse, the patient will be placed on the procedure table in a lithotomy position. The embryologist will show the embryo to the patient on the TV screen and the patient can verify that the name on the dish is correct. The doctor will start to clean the patient’s cervix, and explain each step of the process to the patient during the embryo transfer process.  During the procedure, a vaginal ultrasound will be used to visualize the uterine cavity. After the doctor measure the lining of patient’s endometrium, and checks the placement of the catheter, the embryologist will load the embryo into the catheter. Under the monitor, patients can see the catheter with the embryo as it is inserted into the cervix and advanced into the uterine cavity. The embryo will be deposited in the middle of the uterine cavity.

Recovery Room
 

Life IVF Center is a unique fertility center in Southern California. We specialize in Natural Cycle IVF (NC-IVF) and Minimal Stimulation IVF (MS-IVF). In our center, we will not exclude you for IVF treatment because of your age, number of follicles, FSH or AMH level or financial status. For patients with advanced maternal age, we will try our best to give you a chance to conceive with your own egg.

We understand that conventional IVF treatment is very expensive and stressful. Our goal is to provide a gentle, safe, successful and affordable IVF option to all patients who need assisted reproductive technologies (ART).

Because each patient is different, our treatment protocol for each patient is different. Based on medical conditions and fertility treatment goals, we will design a specific and individualized protocol for each patient.

We believe that natural conception is the best way to have a healthy baby. We will assist patients to achieve pregnancy through a natural method if possible. When a patient needs IVF, we offer a Natural Cycle IVF (NC-IVF) as the first option if she meets the indication. In NC-IVF, patient will complete an IVF treatment without any fertility medication. It is a very safe and cost effective option for many patients.

We also specialize in Minimal Stimulation IVF (MS-IVF), which primarily uses an oral medication with only few injections. Patients will have minimal fertility medication exposure, but achieve comparable IVF outcome as conventional IVF. For some patients, especially with decreased ovarian reserve, it has much better results. It reduces the side effects of medication and significantly decreases the cost of fertility treatment. In our center, we also promote single embryo transfer, which will reduce the multiple gestation. As a state-of-the-art fertility center, we offer full range of fertility services including pre-implantation genetic diagnosis (PGD) and 24 Chromosome PGS, oocyte vitrification, and donor egg and surrogacy program.

We invite you to experience our NC-IVF and MS-IVF. We strive to deliver the most compassionate and personalized care!

Life IVF Center
 

Life IVF Center is a unique fertility center in Southern California. We specialize in Natural Cycle IVF (NC-IVF) and Minimal Stimulation IVF (MS-IVF). In our center, we will not exclude you for IVF treatment because of your age, number of follicles, FSH or AMH level or financial status. For patients with advanced maternal age, we will try our best to give you a chance to conceive with your own egg.

We understand that conventional IVF treatment is very expensive and stressful. Our goal is to provide a gentle, safe, successful and affordable IVF option to all patients who need assisted reproductive technologies (ART).

Because each patient is different, our treatment protocol for each patient is different. Based on medical conditions and fertility treatment goals, we will design a specific and individualized protocol for each patient.

We believe that natural conception is the best way to have a healthy baby. We will assist patients to achieve pregnancy through a natural method if possible. When a patient needs IVF, we offer a Natural Cycle IVF (NC-IVF) as the first option if she meets the indication. In NC-IVF, patient will complete an IVF treatment without any fertility medication. It is a very safe and cost effective option for many patients.

We also specialize in Minimal Stimulation IVF (MS-IVF), which primarily uses an oral medication with only few injections. Patients will have minimal fertility medication exposure, but achieve comparable IVF outcome as conventional IVF. For some patients, especially with decreased ovarian reserve, it has much better results. It reduces the side effects of medication and significantly decreases the cost of fertility treatment. In our center, we also promote single embryo transfer, which will reduce the multiple gestation. As a state-of-the-art fertility center, we offer full range of fertility services including pre-implantation genetic diagnosis (PGD) and 24 Chromosome PGS, oocyte vitrification, and donor egg and surrogacy program.

We invite you to experience our NC-IVF and MS-IVF. We strive to deliver the most compassionate and personalized care!

Life IVF Center
 

Hotel Information

The following hotels offer discounted rates for our patients. Please mention you are a patient of
“Life IVF Center“ when you book the reservation.

Hampton Inn & Suites    2720 Hotel Terrace Drive, Santa Ana, CA 92705  Phone  (714) 556-3838, (800) 861-8148

                                                      
www.santaanaorangecountyairportsuites.hamptoninn.com

You can use the following link to book the hotel directly:
http://hamptoninn.hilton.

   

com/en/hp/reservations/index.jhtml?hotel=STAHSHX&corporateCode=0002836210

Rate: $129 + Tax (Mon/Tue/Wed/Thu)
$89 + Tax (Fri/Sat/Sun)

  • Best Western plus Orange county Airport
     
       
     

                                2700 Hotel Terrace Drive, Santa Ana, CA 92705
(714) 432-8888, (800)432-0053
                                  http://www.bestwestern-oc.com/

             Rate: $79 + Tax                          

  • La Quinta Inn & Suites, Orange County-Santa Ana
    2721 Hotel Terrace Drive, Santa Ana, CA 92705

                                        (714) 540-1111              

   

 

http://www.lq.com/lq/respath/destSearchResults.do?propId=2006&iata=99020724&WT.srch=1&sissr=1

              Rate: $62.10 + Tax                  

      Amenities & Services:

  • Free shuttle to/from John Wane Airport (SNA) and to Life IVF Center
  • Free Breakfast
  • Free Wireless High-Speed Internet Access
  • Free Local Calls
  • Free Newspaper
  • Free Parking
  • Business Center
  • Guest Laundry Facilities
  • Outdoor Swimming Pool
  • Fitness Center

 

Life IVF Center
 

Airport Transportation Information

  1. From  John Wayne, Orange County Airport (SNA): This is the closest airport, only 4.7 miles

(10 minutes) from Life IVF Center.
You may request that your hotel pick you up. Most hotels near the airport offer free shuttle                Service.

  1. From Long Beach Airport (LGB): 25 miles from Life IVF Center

Supper Shuttle: (800) BLUE VAN (800-258-3826)
The shuttle can take you directly to/from your hotel or home
http://www.supershuttle.com/Locations/LGBAirportShuttleLongBeach.aspx

  1. From Los Angeles International Airport (LAX): 45 miles from Life IVF Center

 

  1. Supper Shuttle: (800) BLUE VAN (800-258-3826)

The shuttle can take you directly to/from your hotel or home
http://www.supershuttle.com/Locations/LAXAirportShuttleLosangeles.aspx

  1. Blue Sky Transway : (888) 366-2688, (626) 968-2688

Mandarin speaking available

  1. Lucky Shuttle: (888) 595-8965, (626) 821-0442

Mandarin speaking available

  1. Irvine Shuttle: (949) 735-8822, (949) 244-8889

Mandarin speaking available

  1. California Yellow Cab: (949) 444-4444, (714) 444-4444

http://cayellow.com

 

* All above Shuttle companies are not affiliated with Life IVF Center

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